Grammati worked in private consultancies leading HEOR projects and providing strategic guidance on evidence synthesis and clinical effectiveness analyses for early product value demonstration and HTA submissions. Grammati has gained RWE expertise on leveraging this data for health car decision making through her ISPE leading role in producing guidance documents (such as developing a RWE framework for combining evidence from different sources (work recognized by NICE, EU HTx project), using electronic health records (for COVID-19) and ongoing collaborations with key stakeholders (Harvard Medical School, Utrecht University, NICE).

Grammati has also a strong experience in understanding the payer perspective and requirements through her senior leadership role in the development of NICE Guidelines and closely working with clinicians, patient’s and NICE executives.