Non-persistence/non-adherence in T2DM patients; insights from UK and Germany real-world setting

In our recently published work, we have utilized data from two large retrospective datasets: a German claims dataset and the UK General Practitioner (GP)-based Clinical Practice Research Datalink (CPRD) dataset (2010–2012). The study included 1,905 and 1,627 type 2 diabetes mellitus (T2DM) patients receiving glucagon-like peptide-1 (GLP-1) receptor agonists from the UK and Germany, respectively.

The aim was to assess the level of non-persistence (NP) and non-adherence (NA) to therapy with GLP-1 receptor agonists in T2DM patients. This study is unique from most other adherence studies in analyzing non-persistence and non-adherence separately.

Percentage of NP patients after 12 months was 29.5% in the UK and 36.4% in the German sample. In both countries, a twice-a-day treatment was associated with a higher probability to discontinue a treatment with GLP-1 receptor agonists earlier than a once-a-day treatment. The percentages of patients considered NA were 20.2%/20.0%/20.5% (all/once-a-day/twice-a-day) for the UK sample, and 19.9%/19.2%/ 21.8% (all/once-a-day/twice-a-day) for the German sample. In summary, NP and NA to treatment with GLP-1 receptor agonists in both UK and Germany appear to be similar. Persistence to OD treatment is higher than to BID  treatment in both the UK and Germany.

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