Crossover biases the surrogate endpoints & OS relationship

Do crossover and post-progression treatments bias the relationship between surrogate endpoints and overall survival? In two recent studies, we looked at evidence from 317 trials (78,644 patients) in first-line NSCLC setting (study 1 here) and 146 trials (43,061 patients) in further-line NSCLC setting (study 2 here). The relationship between surrogate endpoints, progression-free survival (PFS) and objective

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Samenloop voor hoop

On 23-24 June, the Ingress-health team participated in a charity event organized by KWF Kanker Bestrijding. By taking turns, our team has walked continuously for 24 hours in Papendrecht, the Netherlands. Additionally, we set up a booth where we took Polaroid pictures and made balloon animals for children. We managed to raise an impressive amount of

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Volleyball Tournament, July 2017

Together with the local home for asylum seekers, the German office of Ingress-health will be participating in a volleyball tournament on July 12th, 2017 in Wismar. This event is part of Ingress’ vision to encourage its team to maintain its work-life balance. Therefore, the team participates at regular sports events throughout the year. As part

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Mixture cure modelling in health economic modelling

More and more potentially curative interventions become available in oncology. Thus, a growing proportion of cancer patients might indeed be cured of their disease. For reimbursement decisions, it is common practice to estimate long-term overall survival based on trial data and for instance parametric survival curves. These standard parametric methods, however, do not explicitly take

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Predicting overall survival in clinical practice

Payers are more interested in effectiveness rather than efficacy of novel treatments. In light of health economics, cost-effectiveness is preferred over cost-efficacy. We aim to assess the use of real-world effectiveness evidence along with efficacy data reported in a clinical trial setting, to estimate effectiveness in a real-world setting with the example of overall survival

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Ingress-helps team at Rostock Marathon Night

The Ingress-health team in the German office will be participating in this year’s relay marathon at Rostock’s marathon night on August 5th, 2017. In a team of 8, we will split the distance of a marathon into shares. The marathon will start at 6 pm and lead the runners through the historic town of Rostock.

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Annual Schwedenlauf, August 2017

Ingress-health first participated in the “Schwedenlauf” – (a local run celebrating the festivities in memory of Wismar’s affiliation to Sweden during and after the thirty years war in the 17th century) – in 2016 and wants to make it a tradition from participating in this run every year. This years’ “Schwedenlauf” will take place on

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Using historical data to inform survival extrapolations

Due to immaturity of survival data in clinical trials at time of health technology assessment, long-term predictions of survival result in uncertainty in decision-making. To predict survival more accurately, we test Bayesian methods using historical data to inform parametric survival predictions based on immature trial data.

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Recent publication: Treatment of German epilepsy patients

The latest manuscript of the INGRESS Real-world data analysis team published addressed the treatment of German focal epilepsy patients – Real life pharmaceutical treatment patterns for adult patients with focal epilepsy in Germany: a longitudinal and cross-sectional analysis of recently approved anti-epileptic drugs. Based on a claims dataset with a total of 34,422 patients diagnosed

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